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ifn α agonist ro8191  (Tocris)


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    Tocris ifn α agonist ro8191
    Ifn α Agonist Ro8191, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ifn+agonist+ro8191/RO+8191/pmc12749486-217-4-12
    Average 93 stars, based on 1 article reviews
    ifn α agonist ro8191 - by Bioz Stars, 2026-10
    93/100 stars

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    other:

    Article Title: Blockade of CC chemokine receptor 2 suppresses pancreatic cancer progression through the interaction with macrophages in the tumor microenvironment.
    Article Snippet: CXCR2 inhibitor SB255002 and IFN- agonist RO8191 were purchased from Calbiochem and TOCRIS, respectively.



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    Elucidating the mechanism of valvular interstitial cell (VIC) subpopulation imbalance during functional tricuspid regurgitation (FTR) progression. A , Temporal differentiation trajectory curves of antifibrotic and profibrotic VIC subpopulations. B , Cell density curve plots of each antifibrotic VIC and profibrotic VIC subpopulation along pseudotime progression. C , Gene cluster heatmap and functional enrichment analysis before and after branched point 1. D , Temporal gene expression profiling of profibrotic and antifibrotic VIC markers. E , Analysis of <t>IFN</t> <t>(interferon)</t> signaling during VIC differentiation. F , Gene Set Enrichment Analysis of TGF (transforming growth factor) β signaling pathway enrichment with FTR disease severity. G , Comparison of IFITM1/3 expression between antifibrotic and profibrotic VICs (Student t test with Welch correction). H , Dot plot showing the IFN signaling intensity during the progression of FTR and functional mitral regurgitation (FMR). I , Immunofluorescence staining of IFITM1 in valve tissues from patients with different FMR stages; scale bar indicates 200 µm. J , Representative immunohistochemical images of the TGFβ signaling activation marker p-SMAD3 at different stages of FTR disease. DAPI indicates 4′,6-diamidino-2-phenylindole; DDRTree, Discriminative Dimensionality Reduction via learning a Tree; ECM, extracellular matrix; GO, gene ontology; IFN, interferon; NES, normalized enrichment score; and TV, tricuspid valve.
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    ifn α agonist ro8191  (Tocris)
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    Tocris ifn α agonist ro8191
    Elucidating the mechanism of valvular interstitial cell (VIC) subpopulation imbalance during functional tricuspid regurgitation (FTR) progression. A , Temporal differentiation trajectory curves of antifibrotic and profibrotic VIC subpopulations. B , Cell density curve plots of each antifibrotic VIC and profibrotic VIC subpopulation along pseudotime progression. C , Gene cluster heatmap and functional enrichment analysis before and after branched point 1. D , Temporal gene expression profiling of profibrotic and antifibrotic VIC markers. E , Analysis of <t>IFN</t> <t>(interferon)</t> signaling during VIC differentiation. F , Gene Set Enrichment Analysis of TGF (transforming growth factor) β signaling pathway enrichment with FTR disease severity. G , Comparison of IFITM1/3 expression between antifibrotic and profibrotic VICs (Student t test with Welch correction). H , Dot plot showing the IFN signaling intensity during the progression of FTR and functional mitral regurgitation (FMR). I , Immunofluorescence staining of IFITM1 in valve tissues from patients with different FMR stages; scale bar indicates 200 µm. J , Representative immunohistochemical images of the TGFβ signaling activation marker p-SMAD3 at different stages of FTR disease. DAPI indicates 4′,6-diamidino-2-phenylindole; DDRTree, Discriminative Dimensionality Reduction via learning a Tree; ECM, extracellular matrix; GO, gene ontology; IFN, interferon; NES, normalized enrichment score; and TV, tricuspid valve.
    Ifn α Agonist Ro8191, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ifn+agonist+ro8191/RO+8191/pmc12749486-217-4-12
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    ifn agonist ro8191  (Tocris)
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    Tocris ifn agonist ro8191
    Elucidating the mechanism of valvular interstitial cell (VIC) subpopulation imbalance during functional tricuspid regurgitation (FTR) progression. A , Temporal differentiation trajectory curves of antifibrotic and profibrotic VIC subpopulations. B , Cell density curve plots of each antifibrotic VIC and profibrotic VIC subpopulation along pseudotime progression. C , Gene cluster heatmap and functional enrichment analysis before and after branched point 1. D , Temporal gene expression profiling of profibrotic and antifibrotic VIC markers. E , Analysis of <t>IFN</t> <t>(interferon)</t> signaling during VIC differentiation. F , Gene Set Enrichment Analysis of TGF (transforming growth factor) β signaling pathway enrichment with FTR disease severity. G , Comparison of IFITM1/3 expression between antifibrotic and profibrotic VICs (Student t test with Welch correction). H , Dot plot showing the IFN signaling intensity during the progression of FTR and functional mitral regurgitation (FMR). I , Immunofluorescence staining of IFITM1 in valve tissues from patients with different FMR stages; scale bar indicates 200 µm. J , Representative immunohistochemical images of the TGFβ signaling activation marker p-SMAD3 at different stages of FTR disease. DAPI indicates 4′,6-diamidino-2-phenylindole; DDRTree, Discriminative Dimensionality Reduction via learning a Tree; ECM, extracellular matrix; GO, gene ontology; IFN, interferon; NES, normalized enrichment score; and TV, tricuspid valve.
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    Average 93 stars, based on 1 article reviews
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    ifn-α receptor 2 agonist ro8191  (Cayman Chemical)
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    Elucidating the mechanism of valvular interstitial cell (VIC) subpopulation imbalance during functional tricuspid regurgitation (FTR) progression. A , Temporal differentiation trajectory curves of antifibrotic and profibrotic VIC subpopulations. B , Cell density curve plots of each antifibrotic VIC and profibrotic VIC subpopulation along pseudotime progression. C , Gene cluster heatmap and functional enrichment analysis before and after branched point 1. D , Temporal gene expression profiling of profibrotic and antifibrotic VIC markers. E , Analysis of <t>IFN</t> <t>(interferon)</t> signaling during VIC differentiation. F , Gene Set Enrichment Analysis of TGF (transforming growth factor) β signaling pathway enrichment with FTR disease severity. G , Comparison of IFITM1/3 expression between antifibrotic and profibrotic VICs (Student t test with Welch correction). H , Dot plot showing the IFN signaling intensity during the progression of FTR and functional mitral regurgitation (FMR). I , Immunofluorescence staining of IFITM1 in valve tissues from patients with different FMR stages; scale bar indicates 200 µm. J , Representative immunohistochemical images of the TGFβ signaling activation marker p-SMAD3 at different stages of FTR disease. DAPI indicates 4′,6-diamidino-2-phenylindole; DDRTree, Discriminative Dimensionality Reduction via learning a Tree; ECM, extracellular matrix; GO, gene ontology; IFN, interferon; NES, normalized enrichment score; and TV, tricuspid valve.
    Ifn α Receptor 2 Agonist Ro8191, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    Elucidating the mechanism of valvular interstitial cell (VIC) subpopulation imbalance during functional tricuspid regurgitation (FTR) progression. A , Temporal differentiation trajectory curves of antifibrotic and profibrotic VIC subpopulations. B , Cell density curve plots of each antifibrotic VIC and profibrotic VIC subpopulation along pseudotime progression. C , Gene cluster heatmap and functional enrichment analysis before and after branched point 1. D , Temporal gene expression profiling of profibrotic and antifibrotic VIC markers. E , Analysis of IFN (interferon) signaling during VIC differentiation. F , Gene Set Enrichment Analysis of TGF (transforming growth factor) β signaling pathway enrichment with FTR disease severity. G , Comparison of IFITM1/3 expression between antifibrotic and profibrotic VICs (Student t test with Welch correction). H , Dot plot showing the IFN signaling intensity during the progression of FTR and functional mitral regurgitation (FMR). I , Immunofluorescence staining of IFITM1 in valve tissues from patients with different FMR stages; scale bar indicates 200 µm. J , Representative immunohistochemical images of the TGFβ signaling activation marker p-SMAD3 at different stages of FTR disease. DAPI indicates 4′,6-diamidino-2-phenylindole; DDRTree, Discriminative Dimensionality Reduction via learning a Tree; ECM, extracellular matrix; GO, gene ontology; IFN, interferon; NES, normalized enrichment score; and TV, tricuspid valve.

    Journal: Arteriosclerosis, Thrombosis, and Vascular Biology

    Article Title: Valvular Leaflets Are Not Innocent Bystanders: Divergent Fibrotic Remodeling Accompanies Functional Mitral and Tricuspid Regurgitation

    doi: 10.1161/ATVBAHA.125.324134

    Figure Lengend Snippet: Elucidating the mechanism of valvular interstitial cell (VIC) subpopulation imbalance during functional tricuspid regurgitation (FTR) progression. A , Temporal differentiation trajectory curves of antifibrotic and profibrotic VIC subpopulations. B , Cell density curve plots of each antifibrotic VIC and profibrotic VIC subpopulation along pseudotime progression. C , Gene cluster heatmap and functional enrichment analysis before and after branched point 1. D , Temporal gene expression profiling of profibrotic and antifibrotic VIC markers. E , Analysis of IFN (interferon) signaling during VIC differentiation. F , Gene Set Enrichment Analysis of TGF (transforming growth factor) β signaling pathway enrichment with FTR disease severity. G , Comparison of IFITM1/3 expression between antifibrotic and profibrotic VICs (Student t test with Welch correction). H , Dot plot showing the IFN signaling intensity during the progression of FTR and functional mitral regurgitation (FMR). I , Immunofluorescence staining of IFITM1 in valve tissues from patients with different FMR stages; scale bar indicates 200 µm. J , Representative immunohistochemical images of the TGFβ signaling activation marker p-SMAD3 at different stages of FTR disease. DAPI indicates 4′,6-diamidino-2-phenylindole; DDRTree, Discriminative Dimensionality Reduction via learning a Tree; ECM, extracellular matrix; GO, gene ontology; IFN, interferon; NES, normalized enrichment score; and TV, tricuspid valve.

    Article Snippet: Concurrently, RO8191, an IFN (interferon) receptor agonist (HY-W063968; MCE ), was used to examine the regulatory effects of IFN pathway activation on the phenotypic transition of valvular interstitial cells (VICs) from an antifibrotic to a profibrotic state.

    Techniques: Functional Assay, Gene Expression, Comparison, Expressing, Immunofluorescence, Staining, Immunohistochemical staining, Activation Assay, Marker